Assay Detail
Binding
CHEMBL1663348
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Inhibition of DPP4 after 20 mins by fluorescence assay
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
The highly potent and selective dipeptidyl peptidase IV inhibitors bearing a thienopyrimidine scaffold effectively treat type 2 diabetes.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 8.62 | 9.48 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1651766 | — | — | 1 | 9.48 |
| CHEMBL1651763 | — | — | 1 | 9.06 |
| CHEMBL1651764 | — | — | 1 | 8.88 |
| CHEMBL1651767 | — | — | 1 | 8.76 |
| CHEMBL376359 | ALOGLIPTIN | 4.0 | 1 | 8.47 |
| CHEMBL1651765 | — | — | 1 | 7.05 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1651766 | — | IC50 | = | 0.33 | nM | 9.48 |
| CHEMBL1651763 | — | IC50 | = | 0.87 | nM | 9.06 |
| CHEMBL1651764 | — | IC50 | = | 1.32 | nM | 8.88 |
| CHEMBL1651767 | — | IC50 | = | 1.72 | nM | 8.76 |
| CHEMBL376359 | ALOGLIPTIN | IC50 | = | 3.4 | nM | 8.47 |
| CHEMBL1651765 | — | IC50 | = | 88.82 | nM | 7.05 |