Assay Detail
Functional
CHEMBL1663417
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiproliferative activity against human MCF7 cells after 4 days by alamar blue assay
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MCF7 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery and SAR of 5-(3-chlorophenylamino)benzo[c][2,6]naphthyridine-8-carboxylic acid (CX-4945), the first clinical stage inhibitor of protein kinase CK2 for the treatment of cancer.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 5.04 | 5.85 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1652737 | — | — | 1 | 5.85 |
| CHEMBL1652707 | — | — | 1 | 5.09 |
| CHEMBL1230165 | SILMITASERTIB | 2.0 | 1 | 5.05 |
| CHEMBL1652704 | — | — | 1 | 4.83 |
| CHEMBL1652738 | — | — | 1 | 4.39 |
| CHEMBL1652706 | — | — | 1 | - |
| CHEMBL1652708 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1652737 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL1652707 | — | IC50 | = | 8200.0 | nM | 5.09 |
| CHEMBL1230165 | SILMITASERTIB | IC50 | = | 8900.0 | nM | 5.05 |
| CHEMBL1652704 | — | IC50 | = | 14700.0 | nM | 4.83 |
| CHEMBL1652738 | — | IC50 | = | 41000.0 | nM | 4.39 |
| CHEMBL1652706 | — | IC50 | - | — | - | |
| CHEMBL1652708 | — | IC50 | - | — | - |