Skip to main content
Free research Free research Free assay review with research home and workspace preview
Quick search ChEMBL 36
Assay Detail

CHEMBL1663702

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Antibiofilm activity in Pseudomonas aeruginosa assessed as inhibition of biofilm formation at 25 degC after 24 hrs
ChEMBL ↗
113
Total Activities
113
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Pseudomonas aeruginosa
Confidence 1 — Organism
Curated By Autocuration

Target

Pseudomonas aeruginosa (CHEMBL348) ↗
Type ORGANISM
Organism Pseudomonas aeruginosa

Publication

Structure-activity relationship of 4(5)-aryl-2-amino-1H-imidazoles, N1-substituted 2-aminoimidazoles and imidazo[1,2-a]pyrimidinium salts as inhibitors of biofilm formation by Salmonella typhimurium and Pseudomonas aeruginosa.
Steenackers HP, Ermolat'ev DS, Savaliya B, De Weerdt A, De Coster D, Shah A, Van der Eycken EV, De Vos DE, Vanderleyden J, De Keersmaecker SC.
J Med Chem (2011) 54 : 472 -484
PubMed 21174477 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 113 4.84 6.00

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL1649887 — — 1 6.00
CHEMBL1649839 — — 1 5.92
CHEMBL1649790 — — 1 5.68
CHEMBL1649791 — — 1 5.68
CHEMBL1649805 — — 1 5.58
CHEMBL1649840 — — 1 5.55
CHEMBL1649773 — — 1 5.50
CHEMBL1649862 — — 1 5.50
CHEMBL1649772 — — 1 5.46
CHEMBL1649806 — — 1 5.40
CHEMBL1649856 — — 1 5.40
CHEMBL1649789 — — 1 5.35
CHEMBL1649851 — — 1 5.35
CHEMBL1649849 — — 1 5.34
CHEMBL1649838 — — 1 5.31
CHEMBL1649836 — — 1 5.31
CHEMBL1649864 — — 1 5.30
CHEMBL1649804 — — 1 5.27
CHEMBL1649803 — — 1 5.22
CHEMBL1649854 — — 1 5.22
CHEMBL1649861 — — 1 5.18
CHEMBL1649793 — — 1 5.17
CHEMBL1649886 — — 1 5.17
CHEMBL1649885 — — 1 5.16
CHEMBL1649807 — — 1 5.10
CHEMBL1649795 — — 1 5.08
CHEMBL1649778 — — 1 5.07
CHEMBL1649882 — — 1 5.06
CHEMBL1649818 — — 1 5.05
CHEMBL1649889 — — 1 5.03

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL1649887 — IC50 = 1000.0 nM 6.00
CHEMBL1649839 — IC50 = 1200.0 nM 5.92
CHEMBL1649791 — IC50 = 2100.0 nM 5.68
CHEMBL1649790 — IC50 = 2100.0 nM 5.68
CHEMBL1649805 — IC50 = 2600.0 nM 5.58
CHEMBL1649840 — IC50 = 2800.0 nM 5.55
CHEMBL1649773 — IC50 = 3200.0 nM 5.50
CHEMBL1649862 — IC50 = 3200.0 nM 5.50
CHEMBL1649772 — IC50 = 3500.0 nM 5.46
CHEMBL1649856 — IC50 = 4000.0 nM 5.40
CHEMBL1649806 — IC50 = 4000.0 nM 5.40
CHEMBL1649789 — IC50 = 4500.0 nM 5.35
CHEMBL1649851 — IC50 = 4500.0 nM 5.35
CHEMBL1649849 — IC50 = 4600.0 nM 5.34
CHEMBL1649836 — IC50 = 4900.0 nM 5.31
CHEMBL1649838 — IC50 = 4900.0 nM 5.31
CHEMBL1649864 — IC50 = 5000.0 nM 5.30
CHEMBL1649804 — IC50 = 5400.0 nM 5.27
CHEMBL1649854 — IC50 = 6000.0 nM 5.22
CHEMBL1649803 — IC50 = 6000.0 nM 5.22
CHEMBL1649861 — IC50 = 6600.0 nM 5.18
CHEMBL1649886 — IC50 = 6800.0 nM 5.17
CHEMBL1649793 — IC50 = 6800.0 nM 5.17
CHEMBL1649885 — IC50 = 7000.0 nM 5.16
CHEMBL1649807 — IC50 = 8000.0 nM 5.10
CHEMBL1649795 — IC50 = 8400.0 nM 5.08
CHEMBL1649778 — IC50 = 8600.0 nM 5.07
CHEMBL1649882 — IC50 = 8700.0 nM 5.06
CHEMBL1649818 — IC50 = 8900.0 nM 5.05
CHEMBL1649889 — IC50 = 9300.0 nM 5.03
CHEMBL1649800 — IC50 = 9800.0 nM 5.01
CHEMBL1649801 — IC50 = 11300.0 nM 4.95
CHEMBL1649855 — IC50 = 11200.0 nM 4.95
CHEMBL1649884 — IC50 = 12700.0 nM 4.90
CHEMBL1649848 — IC50 = 12600.0 nM 4.90
CHEMBL1649853 — IC50 = 13000.0 nM 4.89
CHEMBL1649798 — IC50 = 12800.0 nM 4.89
CHEMBL1649850 — IC50 = 14200.0 nM 4.85
CHEMBL1649868 — IC50 = 14800.0 nM 4.83
CHEMBL1649771 — IC50 = 15000.0 nM 4.82
CHEMBL1649796 — IC50 = 15000.0 nM 4.82
CHEMBL1649880 — IC50 = 15100.0 nM 4.82
CHEMBL1649797 — IC50 = 16300.0 nM 4.79
CHEMBL1649802 — IC50 = 16700.0 nM 4.78
CHEMBL1649845 — IC50 = 17600.0 nM 4.75
CHEMBL1649828 — IC50 = 18700.0 nM 4.73
CHEMBL1649878 — IC50 = 18700.0 nM 4.73
CHEMBL1649794 — IC50 = 18500.0 nM 4.73
CHEMBL1649812 — IC50 = 19100.0 nM 4.72
CHEMBL1649792 — IC50 = 19100.0 nM 4.72