Assay Detail
Functional
CHEMBL1663708
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Antibiofilm activity in Pseudomonas aeruginosa assessed as inhibition of biofilm formation at 37 degC after 24 hrs
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Pseudomonas aeruginosa |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Structure-activity relationship of 4(5)-aryl-2-amino-1H-imidazoles, N1-substituted 2-aminoimidazoles and imidazo[1,2-a]pyrimidinium salts as inhibitors of biofilm formation by Salmonella typhimurium and Pseudomonas aeruginosa.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 4.36 | 4.64 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1649757 | — | — | 1 | 4.64 |
| CHEMBL1649772 | — | — | 1 | 4.53 |
| CHEMBL1649771 | — | — | 1 | 4.32 |
| CHEMBL1649773 | — | — | 1 | 4.29 |
| CHEMBL1649774 | — | — | 1 | 4.03 |
| CHEMBL1649775 | — | — | 1 | - |
| CHEMBL1649776 | — | — | 1 | - |
| CHEMBL1649777 | — | — | 1 | - |
| CHEMBL1649778 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1649757 | — | IC50 | = | 22700.0 | nM | 4.64 |
| CHEMBL1649772 | — | IC50 | = | 29300.0 | nM | 4.53 |
| CHEMBL1649771 | — | IC50 | = | 47600.0 | nM | 4.32 |
| CHEMBL1649773 | — | IC50 | = | 51300.0 | nM | 4.29 |
| CHEMBL1649774 | — | IC50 | = | 94000.0 | nM | 4.03 |
| CHEMBL1649775 | — | IC50 | - | — | - | |
| CHEMBL1649776 | — | IC50 | - | — | - | |
| CHEMBL1649777 | — | IC50 | - | — | - | |
| CHEMBL1649778 | — | IC50 | = | 364600.0 | nM | - |