Assay Detail
Functional
CHEMBL1663718
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Antiprotozoal activity against chloroquine and pyrimethamine-resistant erythrocytic stages of Plasmodium falciparum K1 by [3H]hypoxanthine incorporation assay
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Plasmodium falciparum |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis and antiprotozoal activity of N-alkoxy analogues of the trypanocidal lead compound 4,4'-bis(imidazolinylamino)diphenylamine with improved human blood-brain barrier permeability.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 6.29 | 8.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL242102 | — | — | 1 | 8.05 |
| CHEMBL1650074 | — | — | 1 | 7.26 |
| CHEMBL1650072 | — | — | 1 | 6.70 |
| CHEMBL1650070 | — | — | 1 | 6.35 |
| CHEMBL1650071 | — | — | 1 | 6.23 |
| CHEMBL1650073 | — | — | 1 | 6.12 |
| CHEMBL1650076 | — | — | 1 | 5.87 |
| CHEMBL1650078 | — | — | 1 | 5.74 |
| CHEMBL1650079 | — | — | 1 | 5.71 |
| CHEMBL1650075 | — | — | 1 | 5.61 |
| CHEMBL1650077 | — | — | 1 | 5.58 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL242102 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL1650074 | — | IC50 | = | 55.0 | nM | 7.26 |
| CHEMBL1650072 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL1650070 | — | IC50 | = | 450.0 | nM | 6.35 |
| CHEMBL1650071 | — | IC50 | = | 590.0 | nM | 6.23 |
| CHEMBL1650073 | — | IC50 | = | 750.0 | nM | 6.12 |
| CHEMBL1650076 | — | IC50 | = | 1360.0 | nM | 5.87 |
| CHEMBL1650078 | — | IC50 | = | 1810.0 | nM | 5.74 |
| CHEMBL1650079 | — | IC50 | = | 1940.0 | nM | 5.71 |
| CHEMBL1650075 | — | IC50 | = | 2430.0 | nM | 5.61 |
| CHEMBL1650077 | — | IC50 | = | 2640.0 | nM | 5.58 |