Assay Detail
Binding
CHEMBL1663817
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Inhibition of CHK2 by DELFIA assay
45
Total Activities
45
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Serine/threonine-protein kinase Chk2 (CHEMBL2527) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Structure-based design of potent and selective 2-(quinazolin-2-yl)phenol inhibitors of checkpoint kinase 2.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 45 | 6.84 | 8.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1236782 | — | — | 1 | 8.52 |
| CHEMBL1650128 | — | — | 1 | 8.30 |
| CHEMBL1650131 | — | — | 1 | 8.10 |
| CHEMBL1234108 | — | — | 1 | 8.05 |
| CHEMBL1650129 | — | — | 1 | 7.96 |
| CHEMBL1650126 | — | — | 1 | 7.96 |
| CHEMBL1650125 | — | — | 1 | 7.92 |
| CHEMBL1650130 | — | — | 1 | 7.85 |
| CHEMBL1650117 | — | — | 1 | 7.68 |
| CHEMBL1650123 | — | — | 1 | 7.55 |
| CHEMBL1650119 | — | — | 1 | 7.54 |
| CHEMBL1650127 | — | — | 1 | 7.52 |
| CHEMBL1650056 | — | — | 1 | 7.43 |
| CHEMBL1650105 | — | — | 1 | 7.22 |
| CHEMBL1650110 | — | — | 1 | 7.19 |
| CHEMBL1650106 | — | — | 1 | 7.16 |
| CHEMBL1650121 | — | — | 1 | 7.16 |
| CHEMBL1650122 | — | — | 1 | 7.11 |
| CHEMBL1650115 | — | — | 1 | 7.09 |
| CHEMBL1650107 | — | — | 1 | 7.04 |
| CHEMBL1650124 | — | — | 1 | 6.92 |
| CHEMBL1650055 | — | — | 1 | 6.81 |
| CHEMBL1231179 | — | — | 1 | 6.80 |
| CHEMBL1650100 | — | — | 1 | 6.75 |
| CHEMBL1650113 | — | — | 1 | 6.74 |
| CHEMBL1650118 | — | — | 1 | 6.70 |
| CHEMBL1650109 | — | — | 1 | 6.70 |
| CHEMBL1650103 | — | — | 1 | 6.60 |
| CHEMBL1650120 | — | — | 1 | 6.55 |
| CHEMBL1650114 | — | — | 1 | 6.34 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1236782 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL1650128 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL1650131 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL1234108 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL1650129 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL1650126 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL1650125 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL1650130 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL1650117 | — | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL1650123 | — | IC50 | = | 28.0 | nM | 7.55 |
| CHEMBL1650119 | — | IC50 | = | 29.0 | nM | 7.54 |
| CHEMBL1650127 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL1650056 | — | IC50 | = | 37.0 | nM | 7.43 |
| CHEMBL1650105 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL1650110 | — | IC50 | = | 65.0 | nM | 7.19 |
| CHEMBL1650106 | — | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL1650121 | — | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL1650122 | — | IC50 | = | 78.0 | nM | 7.11 |
| CHEMBL1650115 | — | IC50 | = | 81.0 | nM | 7.09 |
| CHEMBL1650107 | — | IC50 | = | 92.0 | nM | 7.04 |
| CHEMBL1650124 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL1650055 | — | IC50 | = | 154.0 | nM | 6.81 |
| CHEMBL1231179 | — | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL1650100 | — | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL1650113 | — | IC50 | = | 181.0 | nM | 6.74 |
| CHEMBL1650118 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL1650109 | — | IC50 | = | 201.0 | nM | 6.70 |
| CHEMBL1650103 | — | IC50 | = | 250.0 | nM | 6.60 |
| CHEMBL1650120 | — | IC50 | = | 280.0 | nM | 6.55 |
| CHEMBL1650114 | — | IC50 | = | 460.0 | nM | 6.34 |
| CHEMBL1650102 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL1650104 | — | IC50 | = | 510.0 | nM | 6.29 |
| CHEMBL1650093 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL1650097 | — | IC50 | = | 860.0 | nM | 6.07 |
| CHEMBL1650101 | — | IC50 | = | 920.0 | nM | 6.04 |
| CHEMBL1650112 | — | IC50 | = | 1050.0 | nM | 5.98 |
| CHEMBL1649589 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL1650094 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL1650108 | — | IC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL1650096 | — | IC50 | = | 1690.0 | nM | 5.77 |
| CHEMBL1650116 | — | IC50 | = | 2850.0 | nM | 5.54 |
| CHEMBL1650111 | — | IC50 | = | 4600.0 | nM | 5.34 |
| CHEMBL1650099 | — | IC50 | = | 5100.0 | nM | 5.29 |
| CHEMBL1650098 | — | IC50 | = | 5400.0 | nM | 5.27 |
| CHEMBL1650095 | — | IC50 | > | 100000.0 | nM | - |