Assay Detail
Binding
CHEMBL1663818
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Inhibition of CHK1 by DELFIA assay
33
Total Activities
33
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Serine/threonine-protein kinase Chk1 (CHEMBL4630) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Structure-based design of potent and selective 2-(quinazolin-2-yl)phenol inhibitors of checkpoint kinase 2.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 33 | 5.78 | 6.98 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1650128 | — | — | 1 | 6.98 |
| CHEMBL1650126 | — | — | 1 | 6.85 |
| CHEMBL1236782 | — | — | 1 | 6.72 |
| CHEMBL1650125 | — | — | 1 | 6.70 |
| CHEMBL1650129 | — | — | 1 | 6.64 |
| CHEMBL1650127 | — | — | 1 | 6.58 |
| CHEMBL1650124 | — | — | 1 | 6.48 |
| CHEMBL1650121 | — | — | 1 | 6.07 |
| CHEMBL1650119 | — | — | 1 | 6.06 |
| CHEMBL1650123 | — | — | 1 | 6.06 |
| CHEMBL1650105 | — | — | 1 | 6.00 |
| CHEMBL1234108 | — | — | 1 | 5.97 |
| CHEMBL1650122 | — | — | 1 | 5.96 |
| CHEMBL1650109 | — | — | 1 | 5.88 |
| CHEMBL1650130 | — | — | 1 | 5.77 |
| CHEMBL1650115 | — | — | 1 | 5.76 |
| CHEMBL1650110 | — | — | 1 | 5.72 |
| CHEMBL1650117 | — | — | 1 | 5.58 |
| CHEMBL1231179 | — | — | 1 | 5.35 |
| CHEMBL1650131 | — | — | 1 | 5.33 |
| CHEMBL1650120 | — | — | 1 | 5.30 |
| CHEMBL1650113 | — | — | 1 | 4.69 |
| CHEMBL1650093 | — | — | 1 | 4.58 |
| CHEMBL1650114 | — | — | 1 | 4.56 |
| CHEMBL1650055 | — | — | 1 | 4.55 |
| CHEMBL1650116 | — | — | 1 | 4.25 |
| CHEMBL1650118 | — | — | 1 | - |
| CHEMBL1650056 | — | — | 1 | - |
| CHEMBL1650112 | — | — | 1 | - |
| CHEMBL1650111 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1650128 | — | IC50 | = | 105.0 | nM | 6.98 |
| CHEMBL1650126 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL1236782 | — | IC50 | = | 190.0 | nM | 6.72 |
| CHEMBL1650125 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL1650129 | — | IC50 | = | 230.0 | nM | 6.64 |
| CHEMBL1650127 | — | IC50 | = | 260.0 | nM | 6.58 |
| CHEMBL1650124 | — | IC50 | = | 330.0 | nM | 6.48 |
| CHEMBL1650121 | — | IC50 | = | 850.0 | nM | 6.07 |
| CHEMBL1650119 | — | IC50 | = | 870.0 | nM | 6.06 |
| CHEMBL1650123 | — | IC50 | = | 870.0 | nM | 6.06 |
| CHEMBL1650105 | — | IC50 | = | 990.0 | nM | 6.00 |
| CHEMBL1234108 | — | IC50 | = | 1070.0 | nM | 5.97 |
| CHEMBL1650122 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL1650109 | — | IC50 | = | 1320.0 | nM | 5.88 |
| CHEMBL1650130 | — | IC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL1650115 | — | IC50 | = | 1750.0 | nM | 5.76 |
| CHEMBL1650110 | — | IC50 | = | 1910.0 | nM | 5.72 |
| CHEMBL1650117 | — | IC50 | = | 2600.0 | nM | 5.58 |
| CHEMBL1231179 | — | IC50 | = | 4500.0 | nM | 5.35 |
| CHEMBL1650131 | — | IC50 | = | 4650.0 | nM | 5.33 |
| CHEMBL1650120 | — | IC50 | = | 5050.0 | nM | 5.30 |
| CHEMBL1650113 | — | IC50 | = | 20500.0 | nM | 4.69 |
| CHEMBL1650093 | — | IC50 | = | 26000.0 | nM | 4.58 |
| CHEMBL1650114 | — | IC50 | = | 27500.0 | nM | 4.56 |
| CHEMBL1650055 | — | IC50 | = | 28000.0 | nM | 4.55 |
| CHEMBL1650116 | — | IC50 | = | 56000.0 | nM | 4.25 |
| CHEMBL1650118 | — | IC50 | - | — | - | |
| CHEMBL1650056 | — | IC50 | - | — | - | |
| CHEMBL1650112 | — | IC50 | = | 104000.0 | nM | - |
| CHEMBL1650111 | — | IC50 | - | — | - | |
| CHEMBL1650108 | — | IC50 | - | — | - | |
| CHEMBL1650107 | — | IC50 | - | — | - | |
| CHEMBL1650106 | — | IC50 | - | — | - |