Assay Detail
Binding
CHEMBL1663954
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]DTG from sigma 2 receptor in guinea pig brain membrane after 120 mins by liquid scintillation counting
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Cavia porcellus |
| Tissue | Brain |
| Subcellular | Membrane |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Antiproliferative activity of phenylbutyrate ester of haloperidol metabolite II [(±)-MRJF4] in prostate cancer cells.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 4 | 7.93 | 9.01 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1036 | HYDROXYHALOPERIDOL | — | 1 | 9.01 |
| CHEMBL54 | HALOPERIDOL | 4.0 | 1 | 7.80 |
| CHEMBL1649601 | — | — | 1 | 6.98 |
| CHEMBL1469 | PHENYLBUTANOIC ACID | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1036 | HYDROXYHALOPERIDOL | Ki | = | 0.98 | nM | 9.01 |
| CHEMBL54 | HALOPERIDOL | Ki | = | 16.0 | nM | 7.80 |
| CHEMBL1649601 | — | Ki | = | 105.0 | nM | 6.98 |
| CHEMBL1469 | PHENYLBUTANOIC ACID | Ki | > | 10000.0 | nM | - |