Assay Detail
Binding
CHEMBL1664314
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Inhibition of human DPP4
49
Total Activities
49
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Design and synthesis of pyrimidinone and pyrimidinedione inhibitors of dipeptidyl peptidase IV.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 49 | 7.48 | 8.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1650430 | — | — | 1 | 8.52 |
| CHEMBL1650435 | — | — | 1 | 8.40 |
| CHEMBL1650443 | TRELAGLIPTIN | 4.0 | 1 | 8.40 |
| CHEMBL1650411 | — | — | 1 | 8.40 |
| CHEMBL1235761 | — | — | 1 | 8.30 |
| CHEMBL1650423 | — | — | 1 | 8.30 |
| CHEMBL1650420 | — | — | 1 | 8.30 |
| CHEMBL1650422 | — | — | 1 | 8.30 |
| CHEMBL1650434 | — | — | 1 | 8.22 |
| CHEMBL1650404 | — | — | 1 | 8.22 |
| CHEMBL1650408 | — | — | 1 | 8.22 |
| CHEMBL1650429 | — | — | 1 | 8.22 |
| CHEMBL1650405 | — | — | 1 | 8.15 |
| CHEMBL376359 | ALOGLIPTIN | 4.0 | 1 | 8.15 |
| CHEMBL1650440 | — | — | 1 | 8.10 |
| CHEMBL1650432 | — | — | 1 | 8.10 |
| CHEMBL1650433 | — | — | 1 | 8.10 |
| CHEMBL1650426 | — | — | 1 | 8.10 |
| CHEMBL1650406 | — | — | 1 | 8.10 |
| CHEMBL1650449 | — | — | 1 | 8.00 |
| CHEMBL1650409 | — | — | 1 | 8.00 |
| CHEMBL1650418 | — | — | 1 | 7.92 |
| CHEMBL1650439 | — | — | 1 | 7.92 |
| CHEMBL1650413 | — | — | 1 | 7.89 |
| CHEMBL1650403 | — | — | 1 | 7.85 |
| CHEMBL1650441 | — | — | 1 | 7.85 |
| CHEMBL1650410 | — | — | 1 | 7.77 |
| CHEMBL1650424 | — | — | 1 | 7.70 |
| CHEMBL1650428 | — | — | 1 | 7.68 |
| CHEMBL1650427 | — | — | 1 | 7.66 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1650430 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL1650435 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL1650411 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL1650443 | TRELAGLIPTIN | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL1235761 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL1650423 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL1650420 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL1650422 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL1650434 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL1650429 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL1650408 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL1650404 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL1650405 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL376359 | ALOGLIPTIN | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL1650406 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL1650440 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL1650433 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL1650426 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL1650432 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL1650449 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL1650409 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL1650418 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL1650439 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL1650413 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL1650403 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL1650441 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL1650410 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL1650424 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL1650428 | — | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL1650427 | — | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL1650414 | — | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL1650412 | — | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL1650444 | — | IC50 | = | 27.0 | nM | 7.57 |
| CHEMBL1650438 | — | IC50 | = | 36.0 | nM | 7.44 |
| CHEMBL1650436 | — | IC50 | = | 57.0 | nM | 7.24 |
| CHEMBL1650437 | — | IC50 | = | 68.0 | nM | 7.17 |
| CHEMBL1650419 | — | IC50 | = | 77.0 | nM | 7.11 |
| CHEMBL1650421 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL1650416 | — | IC50 | = | 240.0 | nM | 6.62 |
| CHEMBL1650431 | — | IC50 | = | 430.0 | nM | 6.37 |
| CHEMBL1650415 | — | IC50 | = | 540.0 | nM | 6.27 |
| CHEMBL1650425 | — | IC50 | = | 570.0 | nM | 6.24 |
| CHEMBL1650447 | — | IC50 | = | 590.0 | nM | 6.23 |
| CHEMBL1650445 | — | IC50 | = | 830.0 | nM | 6.08 |
| CHEMBL1650442 | — | IC50 | = | 890.0 | nM | 6.05 |
| CHEMBL1650417 | — | IC50 | = | 990.0 | nM | 6.00 |
| CHEMBL1650448 | — | IC50 | = | 3800.0 | nM | 5.42 |
| CHEMBL1650407 | — | IC50 | = | 7400.0 | nM | 5.13 |
| CHEMBL1650446 | — | IC50 | = | 17000.0 | nM | 4.77 |