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Assay Detail

CHEMBL1664437

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of human recombinant MMP2 after 30 mins
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

72 kDa type IV collagenase (CHEMBL333)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Identifying chelators for metalloprotein inhibitors using a fragment-based approach.
Jacobsen JA, Fullagar JL, Miller MT, Cohen SM.
J Med Chem (2011) 54 : 591 -602
PubMed 21189019 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 14 4.69 5.52

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL1650641 1 5.52
CHEMBL1650642 1 5.41
CHEMBL1650643 1 5.37
CHEMBL1650640 1 5.25
CHEMBL1650637 1 5.14
CHEMBL1650639 1 5.08
CHEMBL1650636 1 5.06
CHEMBL1650638 1 4.97
CHEMBL1649594 1 4.12
CHEMBL1650608 1 3.92
CHEMBL310555 OXYQUINOLINE -1.0 1 3.89
CHEMBL121188 TROPOLONE 1 3.84
CHEMBL1650630 1 3.41
CHEMBL734 ACETOHYDROXAMIC ACID 4.0 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL1650641 IC50 = 3000.0 nM 5.52
CHEMBL1650642 IC50 = 3900.0 nM 5.41
CHEMBL1650643 IC50 = 4300.0 nM 5.37
CHEMBL1650640 IC50 = 5600.0 nM 5.25
CHEMBL1650637 IC50 = 7200.0 nM 5.14
CHEMBL1650639 IC50 = 8400.0 nM 5.08
CHEMBL1650636 IC50 = 8800.0 nM 5.06
CHEMBL1650638 IC50 = 10800.0 nM 4.97
CHEMBL1649594 IC50 = 76000.0 nM 4.12
CHEMBL1650608 IC50 = 121000.0 nM 3.92
CHEMBL310555 OXYQUINOLINE IC50 = 130000.0 nM 3.89
CHEMBL121188 TROPOLONE IC50 = 146000.0 nM 3.84
CHEMBL1650630 IC50 = 389000.0 nM 3.41
CHEMBL734 ACETOHYDROXAMIC ACID IC50 = 15000000.0 nM -