Assay Detail
Binding
CHEMBL1664616
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human recombinant PDE5 after 30 mins by fluorescence polarization assay
68
Total Activities
68
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
cGMP-specific 3',5'-cyclic phosphodiesterase (CHEMBL1827) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Synthesis and molecular modeling of novel tetrahydro-β-carboline derivatives with phosphodiesterase 5 inhibitory and anticancer properties.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 68 | 6.33 | 8.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1650866 | — | — | 1 | 8.70 |
| CHEMBL1650676 | — | — | 1 | 8.15 |
| CHEMBL1650673 | — | — | 1 | 8.00 |
| CHEMBL1650869 | — | — | 1 | 8.00 |
| CHEMBL1650690 | — | — | 1 | 7.92 |
| CHEMBL1650862 | — | — | 1 | 7.30 |
| CHEMBL1650865 | — | — | 1 | 7.30 |
| CHEMBL1650686 | — | — | 1 | 7.16 |
| CHEMBL1650674 | — | — | 1 | 7.05 |
| CHEMBL1650677 | — | — | 1 | 6.82 |
| CHEMBL1650880 | — | — | 1 | 6.72 |
| CHEMBL1650867 | — | — | 1 | 6.58 |
| CHEMBL1650854 | — | — | 1 | 6.58 |
| CHEMBL1650876 | — | — | 1 | 6.57 |
| CHEMBL1650879 | — | — | 1 | 6.54 |
| CHEMBL1650680 | — | — | 1 | 6.52 |
| CHEMBL1650695 | — | — | 1 | 6.42 |
| CHEMBL1650667 | — | — | 1 | 6.24 |
| CHEMBL1650683 | — | — | 1 | 6.23 |
| CHEMBL1650861 | — | — | 1 | 6.14 |
| CHEMBL1650675 | — | — | 1 | 6.07 |
| CHEMBL1650864 | — | — | 1 | 6.07 |
| CHEMBL1650868 | — | — | 1 | 6.00 |
| CHEMBL1650877 | — | — | 1 | 5.96 |
| CHEMBL1650863 | — | — | 1 | 5.92 |
| CHEMBL1650885 | — | — | 1 | 5.90 |
| CHEMBL1650881 | — | — | 1 | 5.90 |
| CHEMBL1650882 | — | — | 1 | 5.87 |
| CHEMBL1650870 | — | — | 1 | 5.87 |
| CHEMBL1650684 | — | — | 1 | 5.83 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1650866 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL1650676 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL1650869 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL1650673 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL1650690 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL1650862 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL1650865 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL1650686 | — | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL1650674 | — | IC50 | = | 90.0 | nM | 7.05 |
| CHEMBL1650677 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL1650880 | — | IC50 | = | 190.0 | nM | 6.72 |
| CHEMBL1650867 | — | IC50 | = | 260.0 | nM | 6.58 |
| CHEMBL1650854 | — | IC50 | = | 260.0 | nM | 6.58 |
| CHEMBL1650876 | — | IC50 | = | 270.0 | nM | 6.57 |
| CHEMBL1650879 | — | IC50 | = | 290.0 | nM | 6.54 |
| CHEMBL1650680 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL1650695 | — | IC50 | = | 380.0 | nM | 6.42 |
| CHEMBL1650667 | — | IC50 | = | 570.0 | nM | 6.24 |
| CHEMBL1650683 | — | IC50 | = | 590.0 | nM | 6.23 |
| CHEMBL1650861 | — | IC50 | = | 730.0 | nM | 6.14 |
| CHEMBL1650675 | — | IC50 | = | 850.0 | nM | 6.07 |
| CHEMBL1650864 | — | IC50 | = | 850.0 | nM | 6.07 |
| CHEMBL1650868 | — | IC50 | = | 990.0 | nM | 6.00 |
| CHEMBL1650877 | — | IC50 | = | 1110.0 | nM | 5.96 |
| CHEMBL1650863 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL1650885 | — | IC50 | = | 1270.0 | nM | 5.90 |
| CHEMBL1650881 | — | IC50 | = | 1260.0 | nM | 5.90 |
| CHEMBL1650882 | — | IC50 | = | 1350.0 | nM | 5.87 |
| CHEMBL1650870 | — | IC50 | = | 1340.0 | nM | 5.87 |
| CHEMBL1650684 | — | IC50 | = | 1480.0 | nM | 5.83 |
| CHEMBL1649595 | — | IC50 | = | 1610.0 | nM | 5.79 |
| CHEMBL1650687 | — | IC50 | = | 1870.0 | nM | 5.73 |
| CHEMBL1650873 | — | IC50 | = | 2040.0 | nM | 5.69 |
| CHEMBL1650693 | — | IC50 | = | 2300.0 | nM | 5.64 |
| CHEMBL1650689 | — | IC50 | = | 2310.0 | nM | 5.64 |
| CHEMBL1650678 | — | IC50 | = | 2860.0 | nM | 5.54 |
| CHEMBL1650872 | — | IC50 | = | 3300.0 | nM | 5.48 |
| CHEMBL1650685 | — | IC50 | = | 4140.0 | nM | 5.38 |
| CHEMBL1650878 | — | IC50 | = | 4460.0 | nM | 5.35 |
| CHEMBL1650688 | — | IC50 | = | 6380.0 | nM | 5.20 |
| CHEMBL1650664 | — | IC50 | = | 7200.0 | nM | 5.14 |
| CHEMBL1650679 | — | IC50 | = | 8750.0 | nM | 5.06 |
| CHEMBL1650874 | — | IC50 | - | — | - | |
| CHEMBL1650875 | — | IC50 | - | — | - | |
| CHEMBL1650856 | — | IC50 | - | — | - | |
| CHEMBL1650855 | — | IC50 | - | — | - | |
| CHEMBL1650883 | — | IC50 | - | — | - | |
| CHEMBL1650884 | — | IC50 | - | — | - | |
| CHEMBL1650886 | — | IC50 | - | — | - | |
| CHEMBL1650887 | — | IC50 | - | — | - |