Assay Detail
Binding
CHEMBL1664805
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Inhibition of Aurora A
58
Total Activities
58
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Molecular modeling studies on imidazo[4,5-b]pyridine derivatives as Aurora A kinase inhibitors using 3D-QSAR and docking approaches.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 58 | 6.95 | 8.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1084079 | — | — | 1 | 8.70 |
| CHEMBL1651458 | — | — | 1 | 8.52 |
| CHEMBL1085848 | — | — | 1 | 8.52 |
| CHEMBL1651453 | — | — | 1 | 8.30 |
| CHEMBL1084860 | — | — | 1 | 8.22 |
| CHEMBL1082492 | — | — | 1 | 8.22 |
| CHEMBL1084859 | — | — | 1 | 8.10 |
| CHEMBL1651451 | — | — | 1 | 8.05 |
| CHEMBL1085607 | — | — | 1 | 8.00 |
| CHEMBL1082597 | — | — | 1 | 8.00 |
| CHEMBL1651455 | — | — | 1 | 8.00 |
| CHEMBL1651456 | — | — | 1 | 8.00 |
| CHEMBL1651457 | — | — | 1 | 8.00 |
| CHEMBL1083772 | — | — | 1 | 7.92 |
| CHEMBL1651454 | — | — | 1 | 7.85 |
| CHEMBL1236904 | — | — | 1 | 7.82 |
| CHEMBL1082507 | — | — | 1 | 7.80 |
| CHEMBL1083774 | — | — | 1 | 7.77 |
| CHEMBL1085387 | — | — | 1 | 7.54 |
| CHEMBL1084889 | — | — | 1 | 7.52 |
| CHEMBL1085132 | — | — | 1 | 7.52 |
| CHEMBL1084888 | — | — | 1 | 7.50 |
| CHEMBL1084067 | — | — | 1 | 7.40 |
| CHEMBL392525 | — | — | 1 | 7.38 |
| CHEMBL1085356 | — | — | 1 | 7.30 |
| CHEMBL1082831 | — | — | 1 | 7.28 |
| CHEMBL1085357 | — | — | 1 | 7.28 |
| CHEMBL1085131 | — | — | 1 | 7.26 |
| CHEMBL1086309 | — | — | 1 | 7.26 |
| CHEMBL1086581 | — | — | 1 | 7.26 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1084079 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL1651458 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL1085848 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL1651453 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL1084860 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL1082492 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL1084859 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL1651451 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL1085607 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL1082597 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL1651455 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL1651456 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL1651457 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL1083772 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL1651454 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL1236904 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL1082507 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL1083774 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL1085387 | — | IC50 | = | 29.0 | nM | 7.54 |
| CHEMBL1084889 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL1085132 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL1084888 | — | IC50 | = | 32.0 | nM | 7.50 |
| CHEMBL1084067 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL392525 | — | IC50 | = | 42.0 | nM | 7.38 |
| CHEMBL1085356 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL1082831 | — | IC50 | = | 52.0 | nM | 7.28 |
| CHEMBL1085357 | — | IC50 | = | 53.0 | nM | 7.28 |
| CHEMBL1085131 | — | IC50 | = | 55.0 | nM | 7.26 |
| CHEMBL1086309 | — | IC50 | = | 55.0 | nM | 7.26 |
| CHEMBL1086581 | — | IC50 | = | 55.0 | nM | 7.26 |
| CHEMBL1086557 | — | IC50 | = | 75.0 | nM | 7.12 |
| CHEMBL1083490 | — | IC50 | = | 79.0 | nM | 7.10 |
| CHEMBL1651452 | — | IC50 | = | 81.0 | nM | 7.09 |
| CHEMBL1086219 | — | IC50 | = | 81.0 | nM | 7.09 |
| CHEMBL1082830 | — | IC50 | = | 81.0 | nM | 7.09 |
| CHEMBL1083771 | — | IC50 | = | 115.0 | nM | 6.94 |
| CHEMBL1086556 | — | IC50 | = | 118.0 | nM | 6.93 |
| CHEMBL1085134 | — | IC50 | = | 178.0 | nM | 6.75 |
| CHEMBL1085136 | — | IC50 | = | 210.0 | nM | 6.68 |
| CHEMBL237573 | — | IC50 | = | 250.0 | nM | 6.60 |
| CHEMBL1085135 | — | IC50 | = | 258.0 | nM | 6.59 |
| CHEMBL1651450 | — | IC50 | = | 277.0 | nM | 6.56 |
| CHEMBL395601 | — | IC50 | = | 490.0 | nM | 6.31 |
| CHEMBL236694 | — | IC50 | = | 570.0 | nM | 6.24 |
| CHEMBL1083773 | — | IC50 | = | 650.0 | nM | 6.19 |
| CHEMBL412173 | — | IC50 | = | 870.0 | nM | 6.06 |
| CHEMBL237369 | — | IC50 | = | 2400.0 | nM | 5.62 |
| CHEMBL235232 | — | IC50 | = | 4300.0 | nM | 5.37 |
| CHEMBL1651459 | — | IC50 | = | 4400.0 | nM | 5.36 |
| CHEMBL236938 | — | IC50 | = | 4600.0 | nM | 5.34 |