Assay Detail
Functional
CHEMBL1665866
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiviral activity against HBV harboring RNA polymerase L180M mutant gene infected in human HuH7 cells assessed as decrease in viral transient transfection after 24 hrs
6
Total Activities
3
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Hepatitis B virus |
| Cell Type | Huh-7 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Alkoxyalkyl esters of 9-(s)-(3-hydroxy-2-phosphonomethoxypropyl) adenine are potent and selective inhibitors of hepatitis B virus (HBV) replication in vitro and in HBV transgenic mice in vivo.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 3 | 5.46 | 6.00 |
| EC90 | 3 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL472584 | — | — | 2 | 6.00 |
| CHEMBL922 | ADEFOVIR DIPIVOXIL | 4.0 | 2 | 5.58 |
| CHEMBL141 | LAMIVUDINE | 4.0 | 2 | 4.80 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL472584 | — | EC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL922 | ADEFOVIR DIPIVOXIL | EC50 | = | 2600.0 | nM | 5.58 |
| CHEMBL141 | LAMIVUDINE | EC50 | = | 16000.0 | nM | 4.80 |
| CHEMBL472584 | — | EC90 | = | 3.5 | uM | - |
| CHEMBL141 | LAMIVUDINE | EC90 | = | 41.0 | uM | - |
| CHEMBL922 | ADEFOVIR DIPIVOXIL | EC90 | = | 7.3 | uM | - |