Assay Detail
Functional
CHEMBL1665867
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Antiviral activity against HBV harboring RNA polymerase M204V mutant gene infected in human HuH7 cells assessed as decrease in viral transient transfection after 24 hrs
6
Total Activities
3
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Hepatitis B virus |
| Cell Type | Huh-7 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Alkoxyalkyl esters of 9-(s)-(3-hydroxy-2-phosphonomethoxypropyl) adenine are potent and selective inhibitors of hepatitis B virus (HBV) replication in vitro and in HBV transgenic mice in vivo.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 3 | 5.94 | 6.05 |
| EC90 | 3 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL472584 | — | — | 2 | 6.05 |
| CHEMBL922 | ADEFOVIR DIPIVOXIL | 4.0 | 2 | 5.82 |
| CHEMBL141 | LAMIVUDINE | 4.0 | 2 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL472584 | — | EC50 | = | 900.0 | nM | 6.05 |
| CHEMBL922 | ADEFOVIR DIPIVOXIL | EC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL141 | LAMIVUDINE | EC50 | > | 100000.0 | nM | - |
| CHEMBL472584 | — | EC90 | = | 3.2 | uM | - |
| CHEMBL141 | LAMIVUDINE | EC90 | > | 100.0 | uM | - |
| CHEMBL922 | ADEFOVIR DIPIVOXIL | EC90 | = | 7.2 | uM | - |