Assay Detail
Binding
CHEMBL1666142
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [125I]SDF-1alpha form CXCR4 expressed in CHO cells by scintillation counting
2
Total Activities
1
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Cell Type | CHO |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
The novel CXCR4 antagonist KRH-3955 is an orally bioavailable and extremely potent inhibitor of human immunodeficiency virus type 1 infection: comparative studies with AMD3100.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Activity | 1 | - | - |
| IC50 | 1 | 9.21 | 9.21 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2062277 | — | — | 2 | 9.21 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2062277 | — | IC50 | = | 0.61 | nM | 9.21 |
| CHEMBL2062277 | — | Activity | - | — | - |