Assay Detail
Binding
CHEMBL1666330
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Inhibition of Mab 12G5 binding to CXCR4 W283A mutant expressed in HEK293 cells
4
Total Activities
2
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
The novel CXCR4 antagonist KRH-3955 is an orally bioavailable and extremely potent inhibitor of human immunodeficiency virus type 1 infection: comparative studies with AMD3100.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 7.71 | 8.89 |
| IC90 | 2 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2062277 | — | — | 2 | 8.89 |
| CHEMBL18442 | PLERIXAFOR | 4.0 | 2 | 6.52 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2062277 | — | IC50 | = | 1.3 | nM | 8.89 |
| CHEMBL18442 | PLERIXAFOR | IC50 | = | 300.2 | nM | 6.52 |
| CHEMBL2062277 | — | IC90 | = | 6.9 | nM | - |
| CHEMBL18442 | PLERIXAFOR | IC90 | > | 1000.0 | nM | - |