Assay Detail
Binding
CHEMBL1666331
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of Mab 12G5 binding to CXCR4 I284A mutant expressed in HEK293 cells
4
Total Activities
2
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
The novel CXCR4 antagonist KRH-3955 is an orally bioavailable and extremely potent inhibitor of human immunodeficiency virus type 1 infection: comparative studies with AMD3100.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 7.75 | 8.92 |
| IC90 | 2 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2062277 | — | — | 2 | 8.92 |
| CHEMBL18442 | PLERIXAFOR | 4.0 | 2 | 6.58 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2062277 | — | IC50 | = | 1.2 | nM | 8.92 |
| CHEMBL18442 | PLERIXAFOR | IC50 | = | 265.8 | nM | 6.58 |
| CHEMBL2062277 | — | IC90 | = | 6.8 | nM | - |
| CHEMBL18442 | PLERIXAFOR | IC90 | > | 1000.0 | nM | - |