Assay Detail

CHEMBL1666886

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding

Inhibition of recombinant beta-lactamase RTG3 expressed in Escherichia coli TOP10 by nitrocefin hydrolysis assay

ChEMBL ↗

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Target

Unchecked (CHEMBL612545) ↗

Open DB target context

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Unchecked (CHEMBL612545) is the working anchor for this assay review. Loading the live Open DB target snapshot…

Primary target Unchecked

CHEMBL612545

Anchored from Assay target.

Protein identity Unchecked

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Binding
Confidence	0 — Uncurated / Unknown
Curated By	Autocuration

Target

Unchecked (CHEMBL612545) ↗

Type

UNCHECKED

Publication

Genetic and biochemical characterization of the first extended-spectrum CARB-type beta-lactamase, RTG-4, from Acinetobacter baumannii.

Potron A, Poirel L, Croizé J, Chanteperdrix V, Nordmann P.
Antimicrob Agents Chemother (2009) 53 : 3010 -3016
PubMed 19380596 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
IC50	3	6.90	7.00

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL777	CLAVULANIC ACID	4.0	1	7.00
CHEMBL404	TAZOBACTAM	4.0	1	7.00
CHEMBL403	SULBACTAM	4.0	1	6.70

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL777	CLAVULANIC ACID	IC50	=	100.0	nM	7.00
CHEMBL404	TAZOBACTAM	IC50	=	100.0	nM	7.00
CHEMBL403	SULBACTAM	IC50	=	200.0	nM	6.70