Assay Detail
Binding
CHEMBL1667095
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Inhibition of Escherichia coli MC4100 Beta-Lactamase CMY-30 using cephalothin as reporter substrate
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Escherichia coli |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Extended-spectrum properties of CMY-30, a Val211Gly mutant of CMY-2 cephalosporinase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 8 | 7.07 | 8.64 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL891 | CLOXACILLIN | 4.0 | 1 | 8.64 |
| CHEMBL158 | AZTREONAM | 4.0 | 1 | 7.77 |
| CHEMBL44354 | CEFTAZIDIME | 4.0 | 1 | 6.85 |
| CHEMBL996 | CEFOXITIN | 4.0 | 1 | 6.77 |
| CHEMBL333078 | — | — | 1 | 6.70 |
| CHEMBL1730 | CEFOTAXIME | 4.0 | 1 | 6.52 |
| CHEMBL29 | PENICILLIN G | 4.0 | 1 | 6.22 |
| CHEMBL404 | TAZOBACTAM | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL891 | CLOXACILLIN | Ki | = | 2.3 | nM | 8.64 |
| CHEMBL158 | AZTREONAM | Ki | = | 17.0 | nM | 7.77 |
| CHEMBL44354 | CEFTAZIDIME | Ki | = | 140.0 | nM | 6.85 |
| CHEMBL996 | CEFOXITIN | Ki | = | 170.0 | nM | 6.77 |
| CHEMBL333078 | — | Ki | = | 200.0 | nM | 6.70 |
| CHEMBL1730 | CEFOTAXIME | Ki | = | 300.0 | nM | 6.52 |
| CHEMBL29 | PENICILLIN G | Ki | = | 600.0 | nM | 6.22 |
| CHEMBL404 | TAZOBACTAM | Ki | > | 1000.0 | nM | - |