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Assay Detail

CHEMBL1669856

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Displacement of [125I]IMPY from amyloid beta 1 to 42 after 2 hrs
13
Total Activities
12
Compounds Tested
2
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Confidence 0 — Uncurated / Unknown
Curated By Autocuration

Target

Unchecked (CHEMBL612545)
Type UNCHECKED

Publication

Synthesis and biological evaluation of indole-chalcone derivatives as β-amyloid imaging probe.
Cui M, Ono M, Kimura H, Liu BL, Saji H.
Bioorg Med Chem Lett (2011) 21 : 980 -982
PubMed 21216142 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 12 8.04 8.71
Activity 1 - -

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL240573 2 8.71
CHEMBL1669102 1 8.35
CHEMBL1669101 1 8.29
CHEMBL1669096 1 8.09
CHEMBL1669098 1 8.07
CHEMBL1669094 1 8.07
CHEMBL1669095 1 8.05
CHEMBL78012 1 7.98
CHEMBL1669093 1 7.46
CHEMBL1669100 1 7.29
CHEMBL1669099 1 -
CHEMBL1669097 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL240573 Ki = 1.97 nM 8.71
CHEMBL1669102 Ki = 4.46 nM 8.35
CHEMBL1669101 Ki = 5.17 nM 8.29
CHEMBL1669096 Ki = 8.22 nM 8.09
CHEMBL1669098 Ki = 8.52 nM 8.07
CHEMBL1669094 Ki = 8.43 nM 8.07
CHEMBL1669095 Ki = 8.96 nM 8.05
CHEMBL78012 Ki = 10.5 nM 7.98
CHEMBL1669093 Ki = 35.06 nM 7.46
CHEMBL1669100 Ki = 51.09 nM 7.29
CHEMBL1669099 Ki > 1008.0 nM -
CHEMBL1669097 Ki > 360.0 nM -
CHEMBL240573 Activity - -