Assay Detail

CHEMBL1669996

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding

Displacement of [125I]-Sar1Ile8-angiotensin 2 from angiotensin AT1 receptor in rat adrenal cortical membranes

ChEMBL ↗

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Target

Unchecked (CHEMBL612545) ↗

Open DB target context

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Primary target Unchecked

CHEMBL612545

Anchored from Assay target.

Protein identity Unchecked

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Binding
Organism	Rattus norvegicus
Subcellular	Membrane
Confidence	0 — Uncurated / Unknown
Curated By	Autocuration

Target

Unchecked (CHEMBL612545) ↗

Type

UNCHECKED

Publication

Angiotensin II receptor type 1 (AT1) selective nonpeptidic antagonists--a perspective.

Naik P, Murumkar P, Giridhar R, Yadav MR.
Bioorg Med Chem (2010) 18 : 8418 -8456
PubMed 21071232 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
IC50	1	8.55	8.55
Ki	1	7.74	7.74

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL315021	FORASARTAN	2.0	1	8.55
CHEMBL4524047	—	—	1	7.74

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL315021	FORASARTAN	IC50	=	2.8	nM	8.55
CHEMBL4524047	—	Ki	=	18.4	nM	7.74