Assay Detail
Binding
CHEMBL1669997
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Binding affinity to angiotensin AT1 receptor in bovine adrenal cortex membranes
7
Total Activities
7
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Bos taurus |
| Tissue | Adrenal cortex |
| Subcellular | Membrane |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Angiotensin II receptor type 1 (AT1) selective nonpeptidic antagonists--a perspective.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Activity | 4 | - | - |
| IC50 | 3 | 7.55 | 8.09 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1516 | OLMESARTAN | 3.0 | 1 | 8.09 |
| CHEMBL433895 | — | — | 1 | 7.96 |
| CHEMBL48602 | — | — | 1 | 6.60 |
| CHEMBL62269 | — | — | 1 | - |
| CHEMBL191 | LOSARTAN | 4.0 | 1 | - |
| CHEMBL57242 | AZILSARTAN | 3.0 | 1 | - |
| CHEMBL344546 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1516 | OLMESARTAN | IC50 | = | 8.1 | nM | 8.09 |
| CHEMBL433895 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL48602 | — | IC50 | = | 250.0 | nM | 6.60 |
| CHEMBL62269 | — | Activity | = | 9.3 | nM | - |
| CHEMBL191 | LOSARTAN | Activity | = | 11.6 | nM | - |
| CHEMBL57242 | AZILSARTAN | Activity | = | 4.2 | nM | - |
| CHEMBL344546 | — | Activity | = | 2.5 | nM | - |