Assay Detail
Binding
CHEMBL1669999
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Displacement of radiolabeled angiotensin2 from angiotensin AT1 receptor in rat adrenal cortex membranes
7
Total Activities
7
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Tissue | Adrenal cortex |
| Subcellular | Membrane |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Angiotensin II receptor type 1 (AT1) selective nonpeptidic antagonists--a perspective.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 8.71 | 9.70 |
| Inhibition | 1 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1667886 | — | — | 1 | 9.70 |
| CHEMBL907 | CARBOXYLIC ACID METABOLITE | — | 1 | 9.43 |
| CHEMBL291582 | — | — | 1 | 8.68 |
| CHEMBL443269 | — | — | 1 | 8.51 |
| CHEMBL115021 | — | — | 1 | 8.22 |
| CHEMBL191 | LOSARTAN | 4.0 | 1 | 7.72 |
| CHEMBL1668001 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1667886 | — | IC50 | = | 0.2 | nM | 9.70 |
| CHEMBL907 | CARBOXYLIC ACID METABOLITE | IC50 | = | 0.37 | nM | 9.43 |
| CHEMBL291582 | — | IC50 | = | 2.1 | nM | 8.68 |
| CHEMBL443269 | — | IC50 | = | 3.1 | nM | 8.51 |
| CHEMBL115021 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL191 | LOSARTAN | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL1668001 | — | Inhibition | = | 60.0 | % | - |