Assay Detail
Binding
CHEMBL1670118
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Inhibition of DNA-PK
20
Total Activities
20
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
DNA-dependent protein kinase catalytic subunit (CHEMBL3142) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
DNA-dependent protein kinase (DNA-PK) inhibitors: structure-activity relationships for O-alkoxyphenylchromen-4-one probes of the ATP-binding domain.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 20 | 6.64 | 8.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1086377 | — | — | 1 | 8.30 |
| CHEMBL1669154 | — | — | 1 | 8.10 |
| CHEMBL1669170 | — | — | 1 | 7.85 |
| CHEMBL188678 | — | — | 1 | 7.55 |
| CHEMBL1669157 | — | — | 1 | 7.10 |
| CHEMBL1669167 | — | — | 1 | 6.96 |
| CHEMBL1669165 | — | — | 1 | 6.80 |
| CHEMBL1669161 | — | — | 1 | 6.77 |
| CHEMBL1669160 | — | — | 1 | 6.75 |
| CHEMBL1669158 | — | — | 1 | 6.55 |
| CHEMBL1669156 | — | — | 1 | 6.54 |
| CHEMBL1669159 | — | — | 1 | 6.48 |
| CHEMBL1669166 | — | — | 1 | 6.30 |
| CHEMBL1669155 | — | — | 1 | 6.16 |
| CHEMBL1669168 | — | — | 1 | 6.00 |
| CHEMBL98350 | LY-294002 | -1.0 | 1 | 5.89 |
| CHEMBL1669163 | — | — | 1 | 5.58 |
| CHEMBL1669162 | — | — | 1 | 5.48 |
| CHEMBL1669169 | — | — | 1 | 4.92 |
| CHEMBL1669164 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1086377 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL1669154 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL1669170 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL188678 | — | IC50 | = | 28.0 | nM | 7.55 |
| CHEMBL1669157 | — | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL1669167 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL1669165 | — | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL1669161 | — | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL1669160 | — | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL1669158 | — | IC50 | = | 280.0 | nM | 6.55 |
| CHEMBL1669156 | — | IC50 | = | 290.0 | nM | 6.54 |
| CHEMBL1669159 | — | IC50 | = | 330.0 | nM | 6.48 |
| CHEMBL1669166 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL1669155 | — | IC50 | = | 690.0 | nM | 6.16 |
| CHEMBL1669168 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL98350 | LY-294002 | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL1669163 | — | IC50 | = | 2600.0 | nM | 5.58 |
| CHEMBL1669162 | — | IC50 | = | 3300.0 | nM | 5.48 |
| CHEMBL1669169 | — | IC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL1669164 | — | IC50 | > | 10000.0 | nM | - |