Assay Detail
Binding
CHEMBL1670273
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of glyoxalase 1
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Identification of curcumin derivatives as human glyoxalase I inhibitors: A combination of biological evaluation, molecular docking, 3D-QSAR and molecular dynamics simulation studies.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 7 | 4.45 | 4.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL189171 | ACEMETACIN | 2.0 | 1 | 4.89 |
| CHEMBL6 | INDOMETHACIN | 4.0 | 1 | 4.74 |
| CHEMBL15770 | SULINDAC | 4.0 | 1 | 4.11 |
| CHEMBL1020 | TOLMETIN | 4.0 | 1 | 4.06 |
| CHEMBL19490 | ZOMEPIRAC | 4.0 | 1 | - |
| CHEMBL571 | KETOPROFEN | 4.0 | 1 | - |
| CHEMBL1297 | FENOPROFEN | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL189171 | ACEMETACIN | Ki | = | 12900.0 | nM | 4.89 |
| CHEMBL6 | INDOMETHACIN | Ki | = | 18100.0 | nM | 4.74 |
| CHEMBL15770 | SULINDAC | Ki | = | 77900.0 | nM | 4.11 |
| CHEMBL1020 | TOLMETIN | Ki | = | 87800.0 | nM | 4.06 |
| CHEMBL19490 | ZOMEPIRAC | Ki | = | 107000.0 | nM | - |
| CHEMBL571 | KETOPROFEN | Ki | = | 414000.0 | nM | - |
| CHEMBL1297 | FENOPROFEN | Ki | = | 400000.0 | nM | - |