Assay Detail
Binding
CHEMBL1670320
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Binding affinity to angiotensin AT1 receptor in rat liver membranes
9
Total Activities
9
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Tissue | Liver |
| Subcellular | Membrane |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Angiotensin II receptor type 1 (AT1) selective nonpeptidic antagonists--a perspective.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 8.33 | 9.40 |
| Ki | 2 | 8.91 | 9.12 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL86247 | — | — | 1 | 9.40 |
| CHEMBL80370 | — | — | 1 | 9.32 |
| CHEMBL416477 | — | — | 1 | 9.12 |
| CHEMBL1513 | IRBESARTAN | 4.0 | 1 | 8.89 |
| CHEMBL352257 | — | — | 1 | 8.70 |
| CHEMBL1667998 | — | — | 1 | 8.28 |
| CHEMBL43591 | — | — | 1 | 8.26 |
| CHEMBL191 | LOSARTAN | 4.0 | 1 | 8.17 |
| CHEMBL1668005 | — | — | 1 | 6.00 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL86247 | — | IC50 | = | 0.4 | nM | 9.40 |
| CHEMBL80370 | — | IC50 | = | 0.48 | nM | 9.32 |
| CHEMBL416477 | — | Ki | = | 0.76 | nM | 9.12 |
| CHEMBL1513 | IRBESARTAN | IC50 | = | 1.3 | nM | 8.89 |
| CHEMBL352257 | — | Ki | = | 1.995 | nM | 8.70 |
| CHEMBL1667998 | — | IC50 | = | 5.2 | nM | 8.28 |
| CHEMBL43591 | — | IC50 | = | 5.5 | nM | 8.26 |
| CHEMBL191 | LOSARTAN | IC50 | = | 6.7 | nM | 8.17 |
| CHEMBL1668005 | — | IC50 | = | 1000.0 | nM | 6.00 |