Assay Detail

CHEMBL1670330

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Binding

Displacement of [3H]-angiotensin 2 from angiotensin AT1 receptor

ChEMBL ↗

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Target

Type-1 angiotensin II receptor (CHEMBL227) ↗

Open DB target context

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Type-1 angiotensin II receptor (CHEMBL227) is the working anchor for this assay review. Loading the live Open DB target snapshot…

Primary target Type-1 angiotensin II receptor

CHEMBL227

Anchored from Assay target.

Protein identity Type-1 angiotensin II receptor

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Binding
Confidence	8 — Homologous single protein target
Curated By	Autocuration

Target

Type-1 angiotensin II receptor (CHEMBL227) ↗

Type	SINGLE PROTEIN
Organism	Homo sapiens

Publication

Angiotensin II receptor type 1 (AT1) selective nonpeptidic antagonists--a perspective.

Naik P, Murumkar P, Giridhar R, Yadav MR.
Bioorg Med Chem (2010) 18 : 8418 -8456
PubMed 21071232 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
Ki	1	8.70	8.70

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL304639	ZOLASARTAN	2.0	1	8.70

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL304639	ZOLASARTAN	Ki	=	1.995	nM	8.70