Assay Detail
Functional
CHEMBL1670355
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Antagonist activity at angiotensin AT1 receptor in rat liver membranes
6
Total Activities
6
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Tissue | Liver |
| Subcellular | Membrane |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Angiotensin II receptor type 1 (AT1) selective nonpeptidic antagonists--a perspective.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 7.06 | 8.28 |
| Activity | 1 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL432162 | TASOSARTAN | 2.0 | 1 | 8.28 |
| CHEMBL141019 | — | — | 1 | 7.70 |
| CHEMBL142860 | — | — | 1 | 7.02 |
| CHEMBL142409 | — | — | 1 | 6.46 |
| CHEMBL341724 | — | — | 1 | 5.82 |
| CHEMBL1668004 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL432162 | TASOSARTAN | IC50 | = | 5.2 | nM | 8.28 |
| CHEMBL141019 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL142860 | — | IC50 | = | 96.0 | nM | 7.02 |
| CHEMBL142409 | — | IC50 | = | 350.0 | nM | 6.46 |
| CHEMBL341724 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL1668004 | — | Activity | = | 0.069 | uM | - |