Assay Detail
Binding
CHEMBL1670356
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Binding affinity to angiotensin AT1 receptor in rat adrenal cortical membranes
4
Total Activities
4
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Angiotensin II receptor type 1 (AT1) selective nonpeptidic antagonists--a perspective.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 3 | 8.57 | 9.05 |
| IC50 | 1 | 7.28 | 7.28 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL429847 | MILFASARTAN | 2.0 | 1 | 9.05 |
| CHEMBL422954 | — | — | 1 | 8.59 |
| CHEMBL268004 | — | — | 1 | 8.07 |
| CHEMBL71162 | — | — | 1 | 7.28 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL429847 | MILFASARTAN | Ki | = | 0.9 | nM | 9.05 |
| CHEMBL422954 | — | Ki | = | 2.6 | nM | 8.59 |
| CHEMBL268004 | — | Ki | = | 8.5 | nM | 8.07 |
| CHEMBL71162 | — | IC50 | = | 52.0 | nM | 7.28 |