Assay Detail
Binding
CHEMBL1670498
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Inhibition of human PrkX by RFBA assay
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
cAMP-dependent protein kinase catalytic subunit PRKX (CHEMBL5818) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Optimisation of 6-substituted isoquinolin-1-amine based ROCK-I inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 6.15 | 7.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1667967 | — | — | 1 | 7.10 |
| CHEMBL1667963 | — | — | 1 | 5.20 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1667967 | — | IC50 | = | 79.43 | nM | 7.10 |
| CHEMBL1667963 | — | IC50 | = | 6309.57 | nM | 5.20 |