Assay Detail
Binding
CHEMBL1670499
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Inhibition of PKA by RFBA assay
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Optimisation of 6-substituted isoquinolin-1-amine based ROCK-I inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 5.71 | 6.50 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1667967 | — | — | 1 | 6.50 |
| CHEMBL1667970 | — | — | 1 | 6.40 |
| CHEMBL1667975 | — | — | 1 | 6.30 |
| CHEMBL1667977 | — | — | 1 | 6.20 |
| CHEMBL1667969 | SAR-407899 FREE BASE | 2.0 | 1 | 5.80 |
| CHEMBL1667974 | — | — | 1 | 5.60 |
| CHEMBL1667979 | — | — | 1 | 5.50 |
| CHEMBL1667980 | — | — | 1 | 5.20 |
| CHEMBL1667976 | — | — | 1 | 5.20 |
| CHEMBL1667978 | — | — | 1 | 5.10 |
| CHEMBL1667963 | — | — | 1 | 5.00 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1667967 | — | IC50 | = | 316.23 | nM | 6.50 |
| CHEMBL1667970 | — | IC50 | = | 398.11 | nM | 6.40 |
| CHEMBL1667975 | — | IC50 | = | 501.19 | nM | 6.30 |
| CHEMBL1667977 | — | IC50 | = | 630.96 | nM | 6.20 |
| CHEMBL1667969 | SAR-407899 FREE BASE | IC50 | = | 1584.89 | nM | 5.80 |
| CHEMBL1667974 | — | IC50 | = | 2511.89 | nM | 5.60 |
| CHEMBL1667979 | — | IC50 | = | 3162.28 | nM | 5.50 |
| CHEMBL1667980 | — | IC50 | = | 6309.57 | nM | 5.20 |
| CHEMBL1667976 | — | IC50 | = | 6309.57 | nM | 5.20 |
| CHEMBL1667978 | — | IC50 | = | 7943.28 | nM | 5.10 |
| CHEMBL1667963 | — | IC50 | = | 10000.0 | nM | 5.00 |