Assay Detail
Binding
CHEMBL1670625
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Inhibition of bee venom phospholipase A2 after 5 mins by spectrophotometric analysis
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Apis mellifera |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Chemical and biological explorations of the electrophilic reactivity of the bioactive marine natural product halenaquinone with biomimetic nucleophiles.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 4.94 | 6.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL463914 | MANOALIDE | — | 1 | 6.30 |
| CHEMBL513747 | HELENAQUINONE | — | 1 | 5.43 |
| CHEMBL1668040 | — | — | 1 | 4.89 |
| CHEMBL1667866 | — | — | 1 | 4.75 |
| CHEMBL1668039 | — | — | 1 | 4.62 |
| CHEMBL1668041 | — | — | 1 | 4.46 |
| CHEMBL1668042 | — | — | 1 | 4.12 |
| CHEMBL1214486 | ORHALQUINONE | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL463914 | MANOALIDE | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL513747 | HELENAQUINONE | IC50 | = | 3700.0 | nM | 5.43 |
| CHEMBL1668040 | — | IC50 | = | 12800.0 | nM | 4.89 |
| CHEMBL1667866 | — | IC50 | = | 17700.0 | nM | 4.75 |
| CHEMBL1668039 | — | IC50 | = | 23900.0 | nM | 4.62 |
| CHEMBL1668041 | — | IC50 | = | 34400.0 | nM | 4.46 |
| CHEMBL1668042 | — | IC50 | = | 76800.0 | nM | 4.12 |
| CHEMBL1214486 | ORHALQUINONE | IC50 | = | 1570000.0 | nM | - |