Assay Detail
Binding
CHEMBL1670671
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Binding affinity to angiotensin AT2 receptor
8
Total Activities
7
Compounds Tested
3
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Angiotensin II receptor type 1 (AT1) selective nonpeptidic antagonists--a perspective.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 8.42 | 9.70 |
| Ki | 2 | 7.34 | 8.35 |
| Inhibition | 1 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL7550 | L-158809 | — | 1 | 9.70 |
| CHEMBL58156 | — | — | 2 | 8.64 |
| CHEMBL1668007 | — | — | 1 | 8.46 |
| CHEMBL77029 | — | — | 1 | 8.35 |
| CHEMBL1668008 | — | — | 1 | 8.00 |
| CHEMBL1668009 | — | — | 1 | 7.30 |
| CHEMBL1668003 | — | — | 1 | 6.32 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL7550 | L-158809 | IC50 | = | 0.2 | nM | 9.70 |
| CHEMBL58156 | — | IC50 | = | 2.3 | nM | 8.64 |
| CHEMBL1668007 | — | IC50 | = | 3.5 | nM | 8.46 |
| CHEMBL77029 | — | Ki | = | 4.5 | nM | 8.35 |
| CHEMBL1668008 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL1668009 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL1668003 | — | Ki | = | 480.0 | nM | 6.32 |
| CHEMBL58156 | — | Inhibition | = | 90.0 | % | - |