Assay Detail

CHEMBL1670677

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Functional

Antagonist activity at angiotensin AT1 receptor in rat aorta

ChEMBL ↗

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Target

Unchecked (CHEMBL612545) ↗

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Primary target Unchecked

CHEMBL612545

Anchored from Assay target.

Protein identity Unchecked

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Functional
Organism	Rattus norvegicus
Tissue	Aorta
Confidence	0 — Uncurated / Unknown
Curated By	Autocuration

Target

Unchecked (CHEMBL612545) ↗

Type

UNCHECKED

Publication

Angiotensin II receptor type 1 (AT1) selective nonpeptidic antagonists--a perspective.

Naik P, Murumkar P, Giridhar R, Yadav MR.
Bioorg Med Chem (2010) 18 : 8418 -8456
PubMed 21071232 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
IC50	2	8.90	9.22
Kb	1	-	-

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL158725	—	—	1	9.22
CHEMBL1069	VALSARTAN	4.0	1	8.57
CHEMBL422954	—	—	1	-

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL158725	—	IC50	=	0.6	nM	9.22
CHEMBL1069	VALSARTAN	IC50	=	2.7	nM	8.57
CHEMBL422954	—	Kb	=	2.1	nM	-