Assay Detail
Binding
CHEMBL1670685
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity to angiotensin AT1 receptor in guinea pig adrenal cortex membranes
6
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Cavia porcellus |
| Tissue | Adrenal cortex |
| Subcellular | Membrane |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Type-1 angiotensin II receptor (CHEMBL1671613) ↗| Type | SINGLE PROTEIN |
| Organism | Cavia porcellus |
Publication
Angiotensin II receptor type 1 (AT1) selective nonpeptidic antagonists--a perspective.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 7.64 | 8.42 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL159096 | — | — | 1 | 8.42 |
| CHEMBL418226 | — | — | 1 | 8.30 |
| CHEMBL1668124 | — | — | 1 | 7.62 |
| CHEMBL284536 | — | — | 2 | 7.52 |
| CHEMBL142860 | — | — | 1 | 6.43 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL159096 | — | IC50 | = | 3.8 | nM | 8.42 |
| CHEMBL418226 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL1668124 | — | IC50 | = | 24.0 | nM | 7.62 |
| CHEMBL284536 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL284536 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL142860 | — | IC50 | = | 370.0 | nM | 6.43 |