Assay Detail
Functional
CHEMBL1670754
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of compound 48/80-induced histamine release in rat peritoneal mast cells
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Cell Type | Mast cell |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis and pharmacological evaluation of the individual stereoisomers of 3-[methyl(1,2,3,4-tetrahydro-2-naphthalenyl)amino]-1-indanone, a potent mast cell stabilising agent.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 5.71 | 5.83 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1668409 | — | — | 1 | 5.83 |
| CHEMBL1668408 | — | — | 1 | 5.82 |
| CHEMBL1668410 | — | — | 1 | 5.66 |
| CHEMBL1668407 | — | — | 1 | 5.52 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1668409 | — | IC50 | = | 1490.0 | nM | 5.83 |
| CHEMBL1668408 | — | IC50 | = | 1510.0 | nM | 5.82 |
| CHEMBL1668410 | — | IC50 | = | 2180.0 | nM | 5.66 |
| CHEMBL1668407 | — | IC50 | = | 3030.0 | nM | 5.52 |