Assay Detail
Functional
CHEMBL1670756
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Inhibition of A23187-induced histamine release in rat peritoneal mast cells
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Cell Type | Mast cell |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis and pharmacological evaluation of the individual stereoisomers of 3-[methyl(1,2,3,4-tetrahydro-2-naphthalenyl)amino]-1-indanone, a potent mast cell stabilising agent.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 5.17 | 5.39 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1668408 | — | — | 1 | 5.39 |
| CHEMBL1668410 | — | — | 1 | 5.16 |
| CHEMBL1668409 | — | — | 1 | 5.09 |
| CHEMBL1668407 | — | — | 1 | 5.02 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1668408 | — | IC50 | = | 4080.0 | nM | 5.39 |
| CHEMBL1668410 | — | IC50 | = | 6970.0 | nM | 5.16 |
| CHEMBL1668409 | — | IC50 | = | 8060.0 | nM | 5.09 |
| CHEMBL1668407 | — | IC50 | = | 9480.0 | nM | 5.02 |