Assay Detail
Binding
CHEMBL1670771
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human recombinant VEGFR1 expressed in Sf9 cells after 10 mins
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | Sf9 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Vascular endothelial growth factor receptor 1 (CHEMBL1868) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Isosteric replacement of the Z-enone with haloethyl ketone and E-enone in a resorcylic acid lactone series and biological evaluation.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 5.38 | 7.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1668411 | — | — | 1 | 7.92 |
| CHEMBL1668420 | — | — | 1 | 4.82 |
| CHEMBL1668419 | — | — | 1 | 4.48 |
| CHEMBL1668418 | — | — | 1 | 4.29 |
| CHEMBL1668415 | — | — | 1 | - |
| CHEMBL1651523 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1668411 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL1668420 | — | IC50 | = | 15000.0 | nM | 4.82 |
| CHEMBL1668419 | — | IC50 | = | 33000.0 | nM | 4.48 |
| CHEMBL1668418 | — | IC50 | = | 51000.0 | nM | 4.29 |
| CHEMBL1668415 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL1651523 | — | IC50 | > | 100000.0 | nM | - |