Assay Detail
Binding
CHEMBL1670772
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human recombinant FLT-3 kinase expressed in insect cells after 90 mins
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Receptor-type tyrosine-protein kinase FLT3 (CHEMBL1974) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Isosteric replacement of the Z-enone with haloethyl ketone and E-enone in a resorcylic acid lactone series and biological evaluation.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 5.83 | 8.31 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1668411 | — | — | 1 | 8.31 |
| CHEMBL1668418 | — | — | 1 | 6.48 |
| CHEMBL1668419 | — | — | 1 | 6.48 |
| CHEMBL1668420 | — | — | 1 | 6.23 |
| CHEMBL1651523 | — | — | 1 | 6.07 |
| CHEMBL1668415 | — | — | 1 | 5.62 |
| CHEMBL1668414 | — | — | 1 | 5.60 |
| CHEMBL1668417 | — | — | 1 | 5.15 |
| CHEMBL1668416 | — | — | 1 | 4.92 |
| CHEMBL1668413 | — | — | 1 | 4.80 |
| CHEMBL1668412 | — | — | 1 | 4.47 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1668411 | — | IC50 | = | 4.9 | nM | 8.31 |
| CHEMBL1668418 | — | IC50 | = | 330.0 | nM | 6.48 |
| CHEMBL1668419 | — | IC50 | = | 330.0 | nM | 6.48 |
| CHEMBL1668420 | — | IC50 | = | 590.0 | nM | 6.23 |
| CHEMBL1651523 | — | IC50 | = | 850.0 | nM | 6.07 |
| CHEMBL1668415 | — | IC50 | = | 2400.0 | nM | 5.62 |
| CHEMBL1668414 | — | IC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL1668417 | — | IC50 | = | 7100.0 | nM | 5.15 |
| CHEMBL1668416 | — | IC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL1668413 | — | IC50 | = | 16000.0 | nM | 4.80 |
| CHEMBL1668412 | — | IC50 | = | 34000.0 | nM | 4.47 |