Assay Detail
Binding
CHEMBL1670936
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Inhibition of human aminopeptidase N by Dixon plot analysis
9
Total Activities
9
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Amino-benzosuberone: a novel warhead for selective inhibition of human aminopeptidase-N/CD13.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 5.46 | 5.46 |
| Ki | 4 | 5.31 | 6.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1668623 | — | — | 1 | 6.30 |
| CHEMBL1668626 | — | — | 1 | 6.00 |
| CHEMBL29292 | UBENIMEX | 2.0 | 1 | 5.46 |
| CHEMBL1668624 | — | — | 1 | 4.70 |
| CHEMBL1668630 | — | — | 1 | 4.22 |
| CHEMBL1668625 | — | — | 1 | - |
| CHEMBL1668627 | 2-AMINOCYCLOHEPTANONE HYDROCHLORIDE | — | 1 | - |
| CHEMBL1668628 | — | — | 1 | - |
| CHEMBL1668629 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1668623 | — | Ki | = | 500.0 | nM | 6.30 |
| CHEMBL1668626 | — | Ki | = | 1000.0 | nM | 6.00 |
| CHEMBL29292 | UBENIMEX | IC50 | = | 3500.0 | nM | 5.46 |
| CHEMBL1668624 | — | Ki | = | 20000.0 | nM | 4.70 |
| CHEMBL1668630 | — | Ki | = | 60000.0 | nM | 4.22 |
| CHEMBL1668625 | — | IC50 | > | 1000000.0 | nM | - |
| CHEMBL1668627 | 2-AMINOCYCLOHEPTANONE HYDROCHLORIDE | IC50 | = | 310000.0 | nM | - |
| CHEMBL1668628 | — | IC50 | = | 110000.0 | nM | - |
| CHEMBL1668629 | — | IC50 | = | 300000.0 | nM | - |