Assay Detail
Binding
CHEMBL1670937
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of bovine lens cytosolic leucine aminopeptidase by Dixon plot analysis
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Bos taurus |
| Tissue | Lens of camera-type eye |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Amino-benzosuberone: a novel warhead for selective inhibition of human aminopeptidase-N/CD13.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 9.30 | 9.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL29292 | UBENIMEX | 2.0 | 1 | 9.30 |
| CHEMBL1668623 | — | — | 1 | - |
| CHEMBL1668624 | — | — | 1 | - |
| CHEMBL1668625 | — | — | 1 | - |
| CHEMBL1668626 | — | — | 1 | - |
| CHEMBL1668627 | 2-AMINOCYCLOHEPTANONE HYDROCHLORIDE | — | 1 | - |
| CHEMBL1668628 | — | — | 1 | - |
| CHEMBL1668629 | — | — | 1 | - |
| CHEMBL1668630 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL29292 | UBENIMEX | IC50 | = | 0.5 | nM | 9.30 |
| CHEMBL1668623 | — | IC50 | = | 120000.0 | nM | - |
| CHEMBL1668624 | — | IC50 | > | 1000000.0 | nM | - |
| CHEMBL1668625 | — | IC50 | > | 1000000.0 | nM | - |
| CHEMBL1668626 | — | IC50 | > | 1000000.0 | nM | - |
| CHEMBL1668627 | 2-AMINOCYCLOHEPTANONE HYDROCHLORIDE | IC50 | > | 100000.0 | nM | - |
| CHEMBL1668628 | — | IC50 | > | 1000000.0 | nM | - |
| CHEMBL1668629 | — | IC50 | - | — | - | |
| CHEMBL1668630 | — | IC50 | > | 1000000.0 | nM | - |