Assay Detail
Binding
CHEMBL1671068
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Inhibition of human soluble epoxide hydrolase
19
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
1-(1-acetyl-piperidin-4-yl)-3-adamantan-1-yl-urea (AR9281) as a potent, selective, and orally available soluble epoxide hydrolase inhibitor with efficacy in rodent models of hypertension and dysglycemia.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 19 | 8.03 | 9.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1668928 | — | — | 1 | 9.10 |
| CHEMBL1668937 | — | — | 1 | 8.80 |
| CHEMBL1668940 | — | — | 1 | 8.80 |
| CHEMBL1668935 | — | — | 1 | 8.72 |
| CHEMBL1668939 | — | — | 1 | 8.54 |
| CHEMBL1668936 | — | — | 1 | 8.43 |
| CHEMBL1668930 | — | — | 1 | 8.22 |
| CHEMBL1668938 | — | — | 1 | 8.19 |
| CHEMBL436774 | AR9281 | 2.0 | 1 | 8.10 |
| CHEMBL1668933 | — | — | 1 | 8.00 |
| CHEMBL1668932 | — | — | 1 | 7.96 |
| CHEMBL1668934 | — | — | 1 | 7.92 |
| CHEMBL1668929 | — | — | 1 | 7.89 |
| CHEMBL1668926 | — | — | 1 | 7.85 |
| CHEMBL1668925 | — | — | 1 | 7.60 |
| CHEMBL1668927 | — | — | 1 | 7.54 |
| CHEMBL1668923 | — | — | 1 | 7.24 |
| CHEMBL1668924 | — | — | 1 | 6.92 |
| CHEMBL1668931 | — | — | 1 | 6.73 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1668928 | — | IC50 | = | 0.8 | nM | 9.10 |
| CHEMBL1668937 | — | IC50 | = | 1.6 | nM | 8.80 |
| CHEMBL1668940 | — | IC50 | = | 1.6 | nM | 8.80 |
| CHEMBL1668935 | — | IC50 | = | 1.9 | nM | 8.72 |
| CHEMBL1668939 | — | IC50 | = | 2.9 | nM | 8.54 |
| CHEMBL1668936 | — | IC50 | = | 3.7 | nM | 8.43 |
| CHEMBL1668930 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL1668938 | — | IC50 | = | 6.4 | nM | 8.19 |
| CHEMBL436774 | AR9281 | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL1668933 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL1668932 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL1668934 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL1668929 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL1668926 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL1668925 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL1668927 | — | IC50 | = | 29.0 | nM | 7.54 |
| CHEMBL1668923 | — | IC50 | = | 58.0 | nM | 7.24 |
| CHEMBL1668924 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL1668931 | — | IC50 | = | 185.0 | nM | 6.73 |