Assay Detail
Binding
CHEMBL1671201
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Inhibition of purified His-tagged IKK-beta after 15 mins
19
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Inhibitor of nuclear factor kappa-B kinase subunit beta (CHEMBL1991) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Discovery of imidazo[1,2-b]pyridazines as IKKβ inhibitors. Part 2: improvement of potency in vitro and in vivo.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 19 | 7.42 | 7.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1669334 | — | — | 1 | 7.92 |
| CHEMBL1669337 | — | — | 1 | 7.89 |
| CHEMBL1669342 | — | — | 1 | 7.82 |
| CHEMBL1669340 | — | — | 1 | 7.82 |
| CHEMBL1669333 | — | — | 1 | 7.80 |
| CHEMBL1669335 | — | — | 1 | 7.77 |
| CHEMBL1669336 | — | — | 1 | 7.77 |
| CHEMBL1669341 | — | — | 1 | 7.77 |
| CHEMBL1669332 | — | — | 1 | 7.75 |
| CHEMBL1669328 | — | — | 1 | 7.68 |
| CHEMBL1669329 | — | — | 1 | 7.66 |
| CHEMBL1669326 | — | — | 1 | 7.64 |
| CHEMBL1669331 | — | — | 1 | 7.38 |
| CHEMBL1222990 | — | — | 1 | 7.26 |
| CHEMBL1669327 | — | — | 1 | 7.15 |
| CHEMBL1669330 | — | — | 1 | 7.01 |
| CHEMBL1669339 | — | — | 1 | 6.96 |
| CHEMBL1223203 | — | — | 1 | 6.70 |
| CHEMBL1669338 | — | — | 1 | 5.14 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1669334 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL1669337 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL1669342 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL1669340 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL1669333 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL1669335 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL1669336 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL1669341 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL1669332 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL1669328 | — | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL1669329 | — | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL1669326 | — | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL1669331 | — | IC50 | = | 42.0 | nM | 7.38 |
| CHEMBL1222990 | — | IC50 | = | 55.0 | nM | 7.26 |
| CHEMBL1669327 | — | IC50 | = | 71.0 | nM | 7.15 |
| CHEMBL1669330 | — | IC50 | = | 97.0 | nM | 7.01 |
| CHEMBL1669339 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL1223203 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL1669338 | — | IC50 | = | 7300.0 | nM | 5.14 |