Assay Detail
Unclassified
CHEMBL1671573
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Ratio of product of IC50 for rabbit bone resorption and IC50 for humanized rabbit cathepsin K to IC50 for rabbit cathepsin K
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Unclassified |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Difluoroethylamines as an amide isostere in inhibitors of cathepsin K.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 8.15 | 8.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1669442 | — | — | 1 | 8.70 |
| CHEMBL249495 | — | — | 1 | 8.52 |
| CHEMBL437501 | — | — | 1 | 8.52 |
| CHEMBL1669441 | — | — | 1 | 8.40 |
| CHEMBL481611 | ODANACATIB | 3.0 | 1 | 8.30 |
| CHEMBL1669437 | — | — | 1 | 8.05 |
| CHEMBL1669436 | — | — | 1 | 8.00 |
| CHEMBL1669438 | — | — | 1 | 7.82 |
| CHEMBL1669440 | — | — | 1 | 7.68 |
| CHEMBL1669439 | — | — | 1 | 7.50 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1669442 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL249495 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL437501 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL1669441 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL481611 | ODANACATIB | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL1669437 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL1669436 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL1669438 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL1669440 | — | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL1669439 | — | IC50 | = | 32.0 | nM | 7.50 |