Assay Detail
Functional
CHEMBL1674074
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Antiviral activity against Hepatitis C virus genotype 1b infected in human Huh5-2 cells assessed as reduction in replicon RNA after 4 days by luciferase assay
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Hepacivirus hominis |
| Cell Type | Huh-5-2 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Comparative in vitro anti-hepatitis C virus activities of a selected series of polymerase, protease, and helicase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 15 | 6.17 | 7.72 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1092581 | NESBUVIR | 2.0 | 1 | 7.72 |
| CHEMBL297884 | CILUPREVIR | 2.0 | 1 | 7.40 |
| CHEMBL1651956 | ALISPORIVIR | 3.0 | 1 | 7.22 |
| CHEMBL73809 | — | — | 1 | 6.92 |
| CHEMBL1222314 | THIOPHENE CARBOXYLIC ACID | — | 1 | 6.52 |
| CHEMBL160 | CYCLOSPORINE | 4.0 | 1 | 6.52 |
| CHEMBL231813 | TELAPREVIR | 4.0 | 1 | 6.00 |
| CHEMBL1673142 | — | — | 1 | 5.96 |
| CHEMBL218394 | BOCEPREVIR | 4.0 | 1 | 5.85 |
| CHEMBL393857 | 4'-AZIDOCYTIDINE | -1.0 | 1 | 5.85 |
| CHEMBL176058 | — | — | 1 | 5.75 |
| CHEMBL438605 | — | — | 1 | 5.70 |
| CHEMBL1673141 | — | — | 1 | 5.68 |
| CHEMBL607669 | — | — | 1 | 5.00 |
| CHEMBL177820 | TETRABROMOBENZOTRIAZOLE | — | 1 | 4.40 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1092581 | NESBUVIR | EC50 | = | 19.0 | nM | 7.72 |
| CHEMBL297884 | CILUPREVIR | EC50 | = | 40.0 | nM | 7.40 |
| CHEMBL1651956 | ALISPORIVIR | EC50 | = | 60.0 | nM | 7.22 |
| CHEMBL73809 | — | EC50 | = | 120.0 | nM | 6.92 |
| CHEMBL1222314 | THIOPHENE CARBOXYLIC ACID | EC50 | = | 300.0 | nM | 6.52 |
| CHEMBL160 | CYCLOSPORINE | EC50 | = | 300.0 | nM | 6.52 |
| CHEMBL231813 | TELAPREVIR | EC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL1673142 | — | EC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL218394 | BOCEPREVIR | EC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL393857 | 4'-AZIDOCYTIDINE | EC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL176058 | — | EC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL438605 | — | EC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL1673141 | — | EC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL607669 | — | EC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL177820 | TETRABROMOBENZOTRIAZOLE | EC50 | = | 40000.0 | nM | 4.40 |