Assay Detail
Functional
CHEMBL1674874
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Antiviral activity against Hepatitis C virus GT-1a harboring NS5B polymerase M414T mutant gene
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Hepacivirus hominis |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
GT-1a or GT-1b subtype-specific resistance profiles for hepatitis C virus inhibitors telaprevir and HCV-796.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 2 | 7.22 | 8.15 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1092581 | NESBUVIR | 2.0 | 1 | 8.15 |
| CHEMBL1222314 | THIOPHENE CARBOXYLIC ACID | — | 1 | 6.28 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1092581 | NESBUVIR | EC50 | = | 7.0 | nM | 8.15 |
| CHEMBL1222314 | THIOPHENE CARBOXYLIC ACID | EC50 | = | 530.0 | nM | 6.28 |