Assay Detail
Binding
CHEMBL1675359
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Inhibition of Human immunodeficiency virus 1 integrase
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Human immunodeficiency virus 1 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Human immunodeficiency virus type 1 integrase (CHEMBL3471) ↗| Type | SINGLE PROTEIN |
| Organism | Human immunodeficiency virus 1 |
Publication
Preclinical evaluation of 1H-benzylindole derivatives as novel human immunodeficiency virus integrase strand transfer inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 15 | 6.55 | 8.64 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL414850 | — | — | 1 | 8.64 |
| CHEMBL204656 | ELVITEGRAVIR | 4.0 | 1 | 8.42 |
| CHEMBL254316 | RALTEGRAVIR | 4.0 | 1 | 8.05 |
| CHEMBL260185 | — | — | 1 | 7.22 |
| CHEMBL259011 | — | — | 1 | 6.96 |
| CHEMBL261541 | — | — | 1 | 6.72 |
| CHEMBL19977 | — | — | 1 | 6.70 |
| CHEMBL261714 | — | — | 1 | 6.57 |
| CHEMBL409643 | — | — | 1 | 6.52 |
| CHEMBL1673089 | — | — | 1 | 6.07 |
| CHEMBL260398 | — | — | 1 | 5.91 |
| CHEMBL260619 | — | — | 1 | 5.71 |
| CHEMBL406929 | — | — | 1 | 5.34 |
| CHEMBL405652 | — | — | 1 | 5.32 |
| CHEMBL263887 | — | — | 1 | 4.07 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL414850 | — | IC50 | = | 2.3 | nM | 8.64 |
| CHEMBL204656 | ELVITEGRAVIR | IC50 | = | 3.8 | nM | 8.42 |
| CHEMBL254316 | RALTEGRAVIR | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL260185 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL259011 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL261541 | — | IC50 | = | 190.0 | nM | 6.72 |
| CHEMBL19977 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL261714 | — | IC50 | = | 270.0 | nM | 6.57 |
| CHEMBL409643 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL1673089 | — | IC50 | = | 860.0 | nM | 6.07 |
| CHEMBL260398 | — | IC50 | = | 1240.0 | nM | 5.91 |
| CHEMBL260619 | — | IC50 | = | 1960.0 | nM | 5.71 |
| CHEMBL406929 | — | IC50 | = | 4600.0 | nM | 5.34 |
| CHEMBL405652 | — | IC50 | = | 4760.0 | nM | 5.32 |
| CHEMBL263887 | — | IC50 | = | 86080.0 | nM | 4.07 |