Assay Detail
Binding
CHEMBL1675391
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [125I]ET1 from ETA receptor in CD1 Nu/Nu mouse myocardial ventricles membranes after 2 hrs by gamma counting
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Mus musculus |
| Tissue | Myocardium |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Development and evaluation of endothelin-A receptor (radio)ligands for positron emission tomography.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 8 | 8.49 | 8.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL594482 | — | — | 1 | 8.96 |
| CHEMBL1672880 | — | — | 1 | 8.85 |
| CHEMBL1672881 | — | — | 1 | 8.62 |
| CHEMBL1672883 | — | — | 1 | 8.46 |
| CHEMBL1672884 | — | — | 1 | 8.41 |
| CHEMBL1672882 | — | — | 1 | 8.36 |
| CHEMBL1672885 | — | — | 1 | 8.14 |
| CHEMBL1672886 | — | — | 1 | 8.10 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL594482 | — | Ki | = | 1.1 | nM | 8.96 |
| CHEMBL1672880 | — | Ki | = | 1.4 | nM | 8.85 |
| CHEMBL1672881 | — | Ki | = | 2.4 | nM | 8.62 |
| CHEMBL1672883 | — | Ki | = | 3.5 | nM | 8.46 |
| CHEMBL1672884 | — | Ki | = | 3.9 | nM | 8.41 |
| CHEMBL1672882 | — | Ki | = | 4.4 | nM | 8.36 |
| CHEMBL1672885 | — | Ki | = | 7.3 | nM | 8.14 |
| CHEMBL1672886 | — | Ki | = | 7.9 | nM | 8.10 |