Assay Detail
Binding
CHEMBL1675393
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Selectivity ratio of Ki for ETB receptor in CD1 Nu/Nu mouse myocardial ventricles membranes to Ki for ETA receptor in CD1 Nu/Nu mouse myocardial ventricles membranes
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Mus musculus |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Development and evaluation of endothelin-A receptor (radio)ligands for positron emission tomography.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 8 | 6.58 | 7.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1672883 | — | — | 1 | 7.96 |
| CHEMBL1672884 | — | — | 1 | 7.13 |
| CHEMBL1672885 | — | — | 1 | 6.91 |
| CHEMBL594482 | — | — | 1 | 6.66 |
| CHEMBL1672880 | — | — | 1 | 6.52 |
| CHEMBL1672886 | — | — | 1 | 6.09 |
| CHEMBL1672882 | — | — | 1 | 5.92 |
| CHEMBL1672881 | — | — | 1 | 5.45 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1672883 | — | Ki | = | 11.0 | nM | 7.96 |
| CHEMBL1672884 | — | Ki | = | 74.0 | nM | 7.13 |
| CHEMBL1672885 | — | Ki | = | 122.0 | nM | 6.91 |
| CHEMBL594482 | — | Ki | = | 218.0 | nM | 6.66 |
| CHEMBL1672880 | — | Ki | = | 299.0 | nM | 6.52 |
| CHEMBL1672886 | — | Ki | = | 816.0 | nM | 6.09 |
| CHEMBL1672882 | — | Ki | = | 1214.0 | nM | 5.92 |
| CHEMBL1672881 | — | Ki | = | 3521.0 | nM | 5.45 |