Assay Detail
Binding
CHEMBL1675423
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Binding affinity to HIV1 reverse transcriptase
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Human immunodeficiency virus 1 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Human immunodeficiency virus type 1 reverse transcriptase (CHEMBL247) ↗| Type | SINGLE PROTEIN |
| Organism | Human immunodeficiency virus 1 |
Publication
Anti-human immunodeficiency virus activity, cross-resistance, cytotoxicity, and intracellular pharmacology of the 3'-azido-2',3'-dideoxypurine nucleosides.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 13 | 5.62 | 6.43 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1230 | LAMIVUDINE TRIPHOSPHATE | -1.0 | 1 | 6.43 |
| CHEMBL560403 | DEOXYCYTIDINE TRIPHOSPHATE | — | 1 | 5.96 |
| CHEMBL193952 | ZIDOVUDINE TRIPHOSPHATE | -1.0 | 1 | 5.70 |
| CHEMBL363559 | DEOXYTHYMIDINE_TRIPHOSPHATE | — | 1 | 5.66 |
| CHEMBL1673189 | — | — | 1 | 5.64 |
| CHEMBL485652 | STAVUDINE TRIPHOSPHATE | -1.0 | 1 | 5.57 |
| CHEMBL1201384 | DDCTP | -1.0 | 1 | 5.57 |
| CHEMBL1673190 | — | — | 1 | 5.55 |
| CHEMBL335538 | — | — | 1 | 5.50 |
| CHEMBL1201395 | CARBOVIR 5'-TRIPHOSPHATE, (-)- | -1.0 | 1 | 5.40 |
| CHEMBL477486 | DEOXYGUANOSINE TRIPHOSPHATE | — | 1 | 5.38 |
| CHEMBL1236349 | — | — | 1 | 5.37 |
| CHEMBL1383 | DDA-TRIPHOSPHATE | -1.0 | 1 | 5.28 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1230 | LAMIVUDINE TRIPHOSPHATE | Kd | = | 370.0 | nM | 6.43 |
| CHEMBL560403 | DEOXYCYTIDINE TRIPHOSPHATE | Kd | = | 1100.0 | nM | 5.96 |
| CHEMBL193952 | ZIDOVUDINE TRIPHOSPHATE | Kd | = | 2000.0 | nM | 5.70 |
| CHEMBL363559 | DEOXYTHYMIDINE_TRIPHOSPHATE | Kd | = | 2200.0 | nM | 5.66 |
| CHEMBL1673189 | — | Kd | = | 2300.0 | nM | 5.64 |
| CHEMBL485652 | STAVUDINE TRIPHOSPHATE | Kd | = | 2700.0 | nM | 5.57 |
| CHEMBL1201384 | DDCTP | Kd | = | 2700.0 | nM | 5.57 |
| CHEMBL1673190 | — | Kd | = | 2800.0 | nM | 5.55 |
| CHEMBL335538 | — | Kd | = | 3200.0 | nM | 5.50 |
| CHEMBL1201395 | CARBOVIR 5'-TRIPHOSPHATE, (-)- | Kd | = | 4000.0 | nM | 5.40 |
| CHEMBL477486 | DEOXYGUANOSINE TRIPHOSPHATE | Kd | = | 4200.0 | nM | 5.38 |
| CHEMBL1236349 | — | Kd | = | 4300.0 | nM | 5.37 |
| CHEMBL1383 | DDA-TRIPHOSPHATE | Kd | = | 5300.0 | nM | 5.28 |